{"id":159873,"date":"2017-01-09T20:30:13","date_gmt":"2017-01-10T01:30:13","guid":{"rendered":"\/news\/?p=159873"},"modified":"2017-01-12T14:53:13","modified_gmt":"2017-01-12T19:53:13","slug":"caution-genetic-testing-not-100-accurate","status":"publish","type":"post","link":"https:\/\/archive.liveaction.org\/news\/caution-genetic-testing-not-100-accurate\/","title":{"rendered":"Caution: Genetic testing is not 100% accurate\u00a0"},"content":{"rendered":"
<\/div>

The latest method for prenatal genetic screening involves taking a blood sample from an expectant mother and testing for placental cell-free DNA (cfDNA), which are microscopic fragments of DNA released from the placental cells into the mother\u2019s blood.\u00a0 These tests are used to screen for various genetic abnormalities in a preborn child and to determine the child\u2019s sex. The test can be performed as early as 10 weeks gestation.<\/p>\n

Initially, these tests were only offered to \u201chigh-risk\u201d mothers.\u00a0 Currently, however, they are being offered to all expectant mothers.\u00a0 Tests can be ordered to specifically check for Trisomy 21 (Down\u2019s syndrome) or Trisomy 18 (Edward\u2019s syndrome), but some companies offer the\u00a0screening for more than 250 genetic abnormalities. \u00a0cfDNA testing is less risky than an amniocentesis, in which amniotic fluid is sampled from the sac surrounding the developing baby, or a Chorionic Villus Sampling (CVS), where a sample of cells is taken directly from the wall of the placenta. \u00a0Each of those comes with a risk of miscarriage. While it seems to be a\u00a0simple blood test that can provide a wealth of information, cfDNA genetic testing has risks of its own. Prenatal genetic screening from a sample of maternal blood is not as simple as it sounds because understanding the results and what they truly mean is extremely difficult.\u00a0 Both the mother and her OB\/GYN provider need to be fully informed of the room for error because lives are on the line.<\/p>\n

The main concern, and what needs to be most understood, is that prenatal screening with cfDNA is not diagnostic.\u00a0 It is a screening test<\/i>, one that cannot predict with 100% accuracy whether a baby will have a genetic abnormality.\u00a0 The risks associated with this type of screening can include significant psychological stress to the parents, as well as the death of a child through abortion.\u00a0 Any abnormal screening test must be confirmed with a diagnostic test, either CVS or amniocentesis.\u00a0\u00a0 That said, even these diagnostic tests are not 100% accurate.<\/p>\n

Genetic counseling is a critical component for correctly interpreting these tests and helping providers properly counsel expectant parents.\u00a0 Unfortunately, this does not always occur.\u00a0 There have been several cases where the mothers chose to abort the child after being informed of a positive test, only to find out later that the test was wrong.\u00a0 Others have chosen to carry the child to term, despite the huge emotional stress surrounding their decision, fears, and uncertainty.<\/p>\n

Misdiagnosis of Trisomy 18 leads to abortion\u00a0<\/strong><\/p>\n

In June of 2010, after undergoing an amniocentesis at week 21 of her pregnancy, Anne Meleney-<\/a>Distassio, was informed by her OB\/GYN provider that the results were positive for a serious genetic defect, Trisomy 18, which is considered “incompatible with life”. Children with Trisomy 18 often die before or shortly after birth.\u00a0 In court hearings surrounding this case, it was reported that Meleney-Distassio was informed that the test results were preliminary<\/i>, <\/i>but 99% accurate. Meleney-Distassio claimed that her provider, Dr. Tracy Shevell, MD, had recommended she abort the baby immediately and gave Meleney-Distassio the contact information for an abortion provider.<\/p>\n

The following day Meleney-Distassio terminated her pregnancy only to find out within hours of the abortion that her baby had been misdiagnosed. \u00a0 Meleney-Distassio sued Shevell and Stamford Hospital, and the case was decided in favor of the medical team in November\u00a02016.\u00a0 It was Meleney-Distassio\u2019s word against her OB\/GYN\u2019s.<\/p>\n

Regardless of the outcome of the trial, this was an avoidable tragedy.\u00a0 Had there been a delay in the recommendation or decision to abort, and the patient been referred for further diagnostic tests in combination with genetic counseling, the abortion could have been avoided. In addition, if the medical team had provided Meleney-Distassio with more options, such as speaking with a\u00a0family who had a child with Trisomy 18, the parents may have chosen to carry to term and an innocent life could have been saved from abortion no matter the diagnosis.<\/p>\n

“Accurate” testing leads to misdiagnosis of Trisomy 18<\/strong><\/p>\n

Another story involved a couple from Portland, Oregon, Zachary Diamond and Angie Nunes<\/a>.\u00a0 Their doctor had recommended a blood test for prenatal screening (cfDNA) for genetic abnormalities which they were told was 99% accurate. They were understandably then devastated when their doctor informed them that their baby screened positive for Trisomy 18.\u00a0 Fortunately, the parents waited long enough to undergo an ultrasound and a second screening test which proved the initial screening to be wrong. Their baby was born healthy.<\/p>\n

Misdiagnosis of Trisomy 18 sends mother into a panic<\/strong><\/p>\n

When she was 3 months pregnant, Stacie Chapman<\/a> was informed that her baby\u2019s prenatal screening was positive for Trisomy 18. \u00a0 Chapman was assured that the test was 99% accurate.\u00a0\u00a0 As guidelines recommend, her doctor suggested additional testing to confirm the results.\u00a0 Out of fear that her baby would suffer, and in the midst of this emotional crisis, Champman decided to terminate the pregnancy right away.\u00a0 Thankfully, before proceeding with the abortion, she spent the rest of the day researching Trisomy 18 in an attempt to reinforce her decision.\u00a0\u00a0 Her concerned and conscientious physician called her later that day encouraging her to wait, to defer the abortion until further testing could confirm the results of the screening tests.\u00a0 Fortunately, she took his advice and underwent diagnostic tests, which revealed her son did not have Trisomy 18. \u00a0Chapman gave birth to a healthy baby boy.<\/p>\n

A testing company out of California, Natera Inc.<\/a>, found that 6.2% of women who were told their screening<\/i> test results were positive for high-risk genetic condition decided to terminate their pregnancies prior to obtaining diagnostic tests for confirmation.\u00a0 It is difficult to accurately collect data to verify the actual number of abortions that are the result of genetic testing.\u00a0 Most states are not required to report abortion statistics.\u00a0\u00a0 What is needed is a registry to require the\u00a0collection of data to accurately reflect the number of abortions (surgical and medical) annually – and rationale.\u00a0 This information would be anonymous, without violation of HIPPA laws.\u00a0 This is how the Centers for Disease Control and Prevention (CDC) gathers information currently from states that do report to them.<\/p>\n

As the recommendation for prenatal screening is becoming more common, concerns are growing in the medical field. The American College of Obstetricians and Gynecologists in collaboration with the Society for Maternal-Fetal Medicine published a Committee Opinion<\/a> in September\u00a02015 to address non-invasive cfDNA prenatal screening. They stated that they discourage genetic screening by cfDNA for the general prenatal population:<\/p>\n

Given the performance of conventional screening methods, the limitations of cell-free DNA screening performance, and the limited data on cost effectiveness in the low-risk obstetric population, conventional screening methods remain the most appropriate choice for first-line screening for most women in the general obstetric population.<\/p><\/blockquote>\n

There are also growing concerns regarding the lack of regulation over the development, marketing, and use of these tests.\u00a0 The National Institutes of Health (NIH): National Human Genome Research Institute has on several occasions called for the Food and Drug Administration (FDA) to expand its regulation<\/a> to cover all genetic testing.\u00a0 According to their website, the FDA has yet to take action as of June 21, 2016.<\/p>\n

However, in a November 2015 paper<\/a>\u00a0published by the FDA, noninvasive prenatal screenings were identified as tests with \u201cpotential to yield both many false-positive and false-negative results”. \u00a0The problems identified were:<\/p>\n

    \n
  1. Lack of clinical validation that tests detect and predict fetal abnormalities at an appropriate rate.<\/li>\n
  2. Many false-positive results when used in the general population.<\/li>\n<\/ol>\n

    The personal stories, along with concerns expressed by professional organizations and the FDA\u2019s 2015 paper, reinforce the need for caution when utilizing cfDNA screening tests.\u00a0 They also highlight the need for more direct involvement by genetic counselors and the need for more provider education.\u00a0 Genetic testing is not appropriate, at least at this point, for the general population of low-risk pregnancies.\u00a0 Few things in life are \u201c99%\u201d certain.\u00a0 When lives are at risk, 1% takes on enormous meaning and should not be accepted lightly.<\/p>\n","protected":false},"excerpt":{"rendered":"

    The latest method for prenatal genetic screening involves taking a blood sample from an expectant mother and testing for placental cell-free DNA (cfDNA), which are microscopic fragments of DNA released from the placental cells into the mother\u2019s blood.\u00a0 These tests are used to screen for various genetic abnormalities in a preborn child and to determine […]<\/p>\n","protected":false},"author":440,"featured_media":57359,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false},"categories":[4],"tags":[],"yoast_head":"\nCaution: Genetic testing is not 100 percent accurate\u00a0<\/title>\n<meta name=\"description\" content=\"The risks associated with this screening can include significant psychological stress to the parents, as well as the death of a child through abortion.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" 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Smith, RN, MSN, ACNP, AOCN, has worked in the medical field for over 30 years, specializing in hematology\/oncology. She has published within her profession in both text and peer reviewed journals. She has also been a speaker on the state and national level addressing issues pertinent to hematology\/oncology nursing, and advocacy for her patients and profession. Through advances in genetics, cellular\/molecular and imaging technology (e.g. ultrasound, MRI, CT scanning) in treating cancer, Wendy has gained knowledge and insight into life from stem cells, conception, the embryo and throughout the trajectory of life. Over the years Wendy has volunteered with pregnancy centers, the Navigators, and Prison Fellowship. She has a passion to address pro-life issues from the perspective of a health care provider and science. She understands that \u201cScience is on the side of life\u201d. Wendy is married to her best friend, Fred. 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